Baclofen vs Flexeril: How to Pick One for Your Back Pain

Baclofen vs Flexeril: How to Pick One for Your Back Pain

While all the medicines are effective, one specific muscle relaxant might work better than others for you. A Flexeril overdose occurs when taken in more significant amounts than its prescribed level of 30 mg per day. Overdose can also happen when they both are mixed with alcohol or other drugs.

A Review of Skeletal Muscle Relaxants For Pain Management –

A Review of Skeletal Muscle Relaxants For Pain Management.

Posted: Sun, 18 Dec 2016 01:14:36 GMT [source]

Squares represent the sample size; horizontal lines, the respective 95% confidence intervals of the effect size. Easily book a session with our online doctors to assist you with a wide range of non-life-threatening illnesses (including mental health conditions) from the comfort of your own home. Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

Pain Management: Musculoskeletal Pain

Particularly taking tricyclic antidepressants with Lioresal may lead to muscle weakness. Monoamine Oxidase Inhibitors, if taken with Baclofen, cause lower blood pressure and marked brain function depression. While taking Lioresal, alcoholic beverages should be avoided as Gablofen causes drowsiness and dizziness, which can worsen with alcohol intake. Cyclobenzaprine comes as a tablet and an extended-release capsule to take by mouth.

Then, one or two tablets three to four times per day or more is recommended. In a small number of people, cyclobenzaprine and methocarbamol can cause more serious adverse effects such as allergic reactions with severe rash, swelling, and trouble breathing. If you experience these adverse effects, please seek emergency medical attention.

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Therefore, there needs to be a closer look at Flexeril vs. Baclofen to weigh out the side effects of each. Gablofen is usually prescribed as a long-term treatment for people suffering from long-term diseases such as multiple sclerosis. The medications are not to be used interchangeably because they’re meant to be used for different types of treatments. Whether the patient goes for Baclofen or Flexeril depends on what they need it for. Deciding between the two depends on factors such as the type of muscle spasm or pain you are experiencing and their possible side effects and dosing.

Baclofen vs. Flexeril

If benefits are not evident after a reasonable trial period, patients should be slowly withdrawn from the drug. The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site. Chemically, baclofen is related to gamma-aminobutyric acid (GABA), a naturally occurring neurotransmitter in the brain. Neurotransmitters are chemicals that nerves use to communicate with one another. GABA released by some nerves causes the activity of other nerves to decrease.

By inhibiting these signals, cyclobenzaprine reduces or even eliminates muscle spasms. Baclofen dissipates rapidly after administration (due to its short half-life), and so must be administered every hours for optimal effect. People who use baclofen often require dosage increases over time to maintain the same therapeutic effects (2). Your doctor will help you determine the right dose for your particular case. Baclofen can be administered orally or intrathecally through a surgically inserted spinal cord pump.

  • The goals of treatment include managing muscle pain and improving functional status so the patient can return to work or resume previous activities.
  • Both drugs are skeletal muscle relaxants or antispasmodic agents, but they contain different active ingredients.
  • The dosage may then be increased to 10 mg orally three times a day based on how the person responds.
  • By standardization, the study results are transformed to a common scale (SD units) that facilitates pooling.
  • Therefore, you should wait and see how these medications affect you before driving a motor vehicle or operating machinery.

One study found that patients with acute lower back pain treated with ibuprofen (NSAID) alone had similar pain and function levels to patients treated with baclofen and ibuprofen (7). Patients treated with cyclobenzaprine were significantly more likely to experience adverse effects (Table 3). Fifty-three percent of the patients receiving cyclobenzaprine experienced at least one adverse effect, compared with 28% receiving placebo.

What Are Possible Side Effects of Baclofen?

Our team does their best for our readers to help them stay informed about vital healthcare decisions. After successful graduation from Boston University, MA, Sharon gained a Master’s degree in Public Health. Both Cyclobenzaprine and Tizanidine can interfere with other drugs you may be taking, especially those that affect the central nervous system, including barbiturates and opioids. In comparison, Tizanidine is more direct – blocking the nerve signals in the brain, reducing activity of the muscles that cause muscles to spasm.


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